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LONDON, March 28 (Xinhua) -- Altering the gut microbes of mice can reduce brain damage after a stroke , which highlights a previously unrecognized link between the intestine and the brain, according to a study published online Monday in the journal Nature Medicine.
The microbiome, communities of microbes, colonize the gut and other barrier surfaces in the body early in life, and they have a pronounced influence on the development of the immune system and on metabolic processes. Alterations in the microbiome have been identified in several diseases , including inflammatory bowel disease, obesity and asthma, and they influence disease outcome.
A team of U.S. researchers used a mouse model of stroke to show that microbes in the gut regulate the development of pro-inflammatory immune cells, which migrate from the intestine to the brain after a stroke is induced.
The researchers treated mice with antibiotics. Two weeks later, the researchers induced the most common type of stroke , called ischemic stroke. Mice treated with antibiotics experienced a stroke that was about 60 percent smaller than rodents that did not receive the medication.
They found that the medication shifted the balance of pro- and anti-inflammatory immune cell types in the gut, increasing the number of anti-inflammatory T cells present. These microbial shifts ultimately reduce the number of pro-infla.